Giant Papillary Conjunctivitis or GPC, is typically associated with contact lens wear. Symptoms include, contact lens discomfort and fluctuating vision. There is often mucus discharge from one or both eyes. A particularly annoying symptom of GPC is dislocation and excess movement of the contact lens.
GPC may occur months or even years after you begin contact lens wear. Among the things that may cause GPC are improper cleaning of contact lenses, infrequent contact lens replacement, and wearing contact lenses for too many hours.
There are tiny papilla on the inside of the upper eyelid normally. Allergies can cause the papilla to swell and secrete histamine which causes itchy eyes. In GPC, the papilla greatly enlarge due to interaction with foreign bodies such as debris on the contact lens or the contact lens itself. The large papilla secrete sticky proteins which adhere to the contact lens causing more debris and forcing the lens to move out of place.
Resolution of GPC includes decrease or cessation of contact lens wear, and often treatment with topical cortico-steroids and mast-cell inhibitors eyedrops. Contact lens wear can usually be resumed with modifications in the lens type and care regime.